Common metabolites and reducing/chelating agents do not mobilize iron from intracellular ferritin but can (like lysosomal extracts) dissolve ferritin iron mineral
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چکیده
منابع مشابه
Release of iron from ferritin requires lysosomal activity.
How ferritin-Fe becomes available for cell functions is unknown. Our previous studies with rat hepatoma cells indicated ferritin had to be degraded to release its Fe. In these studies, we investigated whether this occurs in other cell types and whether lysosomes are required. Release of ferritin-Fe was induced with desferoxamine (DFO) in (59)Fe-preloaded hepatoma, Caco2, and erythroid K562 cell...
متن کاملIron, ferritin, and nutrition.
Ferritin, a major form of endogenous iron in food legumes such as soybeans, is a novel and natural alternative for iron supplementation strategies where effectiveness is limited by acceptability, cost, or undesirable side effects. A member of the nonheme iron group of dietary iron sources, ferritin is a complex with Fe3+ iron in a mineral (thousands of iron atoms inside a protein cage) protecte...
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Bacterial ferritin from Azotobacter vinelandii (AvBFJ has a function in H2 uptake. The Fe3+ reduction on the surface of the iron core from AvBF0 is accompanied simultaneously by H2 uptake, with a maximum activity of H2 uptake of 450 H2/AvBF0. A reduction potential of -402 mV for iron reduction on the surface of the core is found. A shift to the red the protein absorbance peaks ranging from 280 ...
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The iron absorption from ferritin and hemosiderin biosynthetically labeled with radioiron was studied in 108 subjects. The geometric mean absorption of ferritin iron in both normal and iron-deficient subjects was 1.9 percent. Its mean absorption ranged from 0.9 percent in normal subjects to 2.5 percent in subjects with moderate iron deficiency and 5.7 percent in subjects with marked iron defici...
متن کاملIron in cytosolic ferritin can be recycled through lysosomal degradation in human fibroblasts.
Examination of the mechanism of intracellular iron recovery from lysosomally-degraded ferritin in vivo has been complicated by the continuous flux of cellular iron through ferritin molecules. Here we incubated human fibroblasts with cationic ferritin, a derivative of horse spleen ferritin, as a technique for delivering immunologically distinct ferritin molecules directly to lysosomes. Using thi...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.717.17